Bioinformatics

GENE AND PROMOTER PREDICTION MCQs

Total Questions : 82

Page 1 of 9 pages
Question 1. Which of the following is true regarding the methods of gene prediction?
  1.    They solely consist of a type called ab initio–based methods
  2.    The ab initio–based approach predicts genes based on the given sequence alone
  3.    The ab initio–based approach predicts genes based on the given sequence and relative homology data
  4.    They solely consist of a type called homology-based approaches
 Discuss Question
Answer is Option B. -> The ab initio–based approach predicts genes based on the given sequence alone
Answer: (b).The ab initio–based approach predicts genes based on the given sequence alone
Question 2. In the ab initio–based approaches—they rely on two major features associated with genes: one of them being the existence of gene signals, which include start and stop codons, intron splice signals, transcription factor binding sites, etc.
  1.    True
  2.    False
  3.    May be True or False
  4.    Can't say
 Discuss Question
Answer is Option A. -> True
Answer: (a).True
Question 3. In the ab initio–based approaches—they rely on two major features associated with genes: one of them being gene content, which is statistical description of coding regions.
  1.    True
  2.    False
  3.    May be True or False
  4.    Can't say
 Discuss Question
Answer is Option A. -> True
Answer: (a).True
Question 4. The homology-based method makes predictions based on significant matches of the query sequence with sequences of known genes.
  1.    True
  2.    False
  3.    May be True or False
  4.    Can't say
 Discuss Question
Answer is Option A. -> True
Answer: (a).True
Question 5. FGENESB is a web-based program that is also based on fifth-order HMMs for detecting coding regions.
  1.    True
  2.    False
  3.    May be True or False
  4.    Can't say
 Discuss Question
Answer is Option A. -> True
Answer: (a).True
Question 6. The advantage of the ab initio method is that the sequence can be applied as such without having to obtain experimental information.
  1.    True
  2.    False
  3.    May be True or False
  4.    Can't say
 Discuss Question
Answer is Option A. -> True
Answer: (a).True
Question 7. Ab initio type of algorithm predicts prokaryotic and eukaryotic promoters and regulatory elements based on characteristic sequences patterns for promoters and regulatory elements.
  1.    True
  2.    False
  3.    May be True or False
  4.    Can't say
 Discuss Question
Answer is Option A. -> True
Answer: (a).True
Question 8. Operon prediction is less important in prokaryotic promoter prediction.
  1.    True
  2.    False
  3.    May be True or False
  4.    Can't say
 Discuss Question
Answer is Option B. -> False
Answer: (b).False
Question 9. To improve the specificity of prediction, some algorithms selectively ______ coding regions and focus on the upstream regions________ which are most likely to contain promoters. In that sense, promoter prediction and gene prediction are coupled.
  1.    include, (0.5 to 2.0 kb) only
  2.    include, (0.5 to 2.0 Mb) only
  3.    exclude, (0.5 to 2.0 Mb) only
  4.    exclude, (0.5 to 2.0 kb) only
 Discuss Question
Answer is Option D. -> exclude, (0.5 to 2.0 kb) only
Answer: (d).exclude, (0.5 to 2.0 kb) only
Question 10. Which of the following is incorrect regarding the ab initio approaches?
  1.    The conventional approach to detecting a promoter or regulatory site is through matching a consensus sequence pattern represented by regular expressions
  2.    The conventional approach to detecting a promoter or regulatory site is through matching a position-specific scoring matrix constructed from well-characterized binding sites
  3.    The consensus sequences or the matrices are relatively short, covering 6 to 10 bases
  4.    The consensus sequences or the matrices are relatively large, covering 700 to 1000 bases
 Discuss Question
Answer is Option D. -> The consensus sequences or the matrices are relatively large, covering 700 to 1000 bases
Answer: (d).The consensus sequences or the matrices are relatively large, covering 700 to 1000 bases