Questions and answers for exam Preparation

MCQs

Total Questions : 82 | Page 5 of 9 pages

Question 41. Most vertebrate genes use __________ as the translation start codon and have a uniquely conserved flanking sequence call a Kozak sequence (CCGCCATGG).

Discuss Question

Answer: Option B. -> ATG
Answer: (b).ATG

Question 42. Which of the following is untrue about translation and transcription?

The first is capping is at the 5’ end of the transcript which involves methylation at the initial residue of the RNA
The splicing process involves a large RNA-protein complex called spliceosome
The second event is splicing, which is the process of removing exons and joining introns
The second event is splicing, which is the process of removing introns and joining exons

Discuss Question

Answer: Option C. -> The second event is splicing, which is the process of removing exons and joining introns
Answer: (c).The second event is splicing, which is the process of removing exons and joining introns

Question 43. In Ab Initio–Based Programs for Gene Prediction– Gene content refers to coding statistics, which includes nonrandom nucleotide distribution, amino acid distribution, synonymous codon usage, and hexamer frequencies.

True
False
May be True or False
Can't say

Discuss Question

Answer: Option A. -> True
Answer: (a).True

Question 44. GRAIL is a web-based program that is based on a neural network algorithm Which is trained on several statistical features such as splice junctions, start and stop codons, poly-A sites, promoters, and CpG islands.

True
False
May be True or False
Can't say

Discuss Question

Answer: Option A. -> True
Answer: (a).True

Question 45. Which of the following is untrue about PredictionUsing NeuralNetworks for Gene Prediction?

A neural network is a statistical model with a special architecture for pattern recognition and classification
It is composed of a network of mathematical variables
They resembles ab initio approaches
The variables in NeuralNetworks resemble the biological nervous system, with variables or nodes connected by weighted functions that are analogous to synapses

Discuss Question

Answer: Option C. -> They resembles ab initio approaches
Answer: (c).They resembles ab initio approaches

Question 46. Which of the following is untrue about Prediction Using Neural Networks for Gene Prediction?

A neural network is constructed with multiple layers; the input, output, and hidden layers
The input is the gene sequence with intron and exon signals
The model is not fed with a sequence of known gene structure
The output is the probability of an exon structure

Discuss Question

Answer: Option C. -> The model is not fed with a sequence of known gene structure
Answer: (c).The model is not fed with a sequence of known gene structure

Question 47. Which of the following is untrue about Prediction Using Discriminant Analysis for Gene Prediction?

QDA draws a curved line based on a quadratic function
LDA works by drawing a diagonal line that best separates coding signals from noncoding signals based on knowledge learned from training data sets of known gene structures
Some gene prediction algorithms rely on discriminant analysis, either LDA or quadratic discriminant analysis (QDA), to improve accuracy
LDA works by plotting a three-dimensional graph of coding signals versus all potential 3’ splice site positions

Discuss Question

Answer: Option D. -> LDA works by plotting a three-dimensional graph of coding signals versus all potential 3’ splice site positions
Answer: (d).LDA works by plotting a three-dimensional graph of coding signals versus all potential 3’ splice site positions

Question 48. Which of the following is untrue about FGENES?

It stands for FindGenes
It is a web-based program that uses LDA
It is used to determine whether a signal is an exon
It does not make a use of HMMs

Discuss Question

Answer: Option D. -> It does not make a use of HMMs
Answer: (d).It does not make a use of HMMs

Question 49. The drawback of Homology-based approach is its reliance on the presence of homologs in databases.

True
False
May be True or False
Can't say

Discuss Question

Answer: Option A. -> True
Answer: (a).True

Question 50. Which of the following wrong about HMM GENE?

It is also an HMM-based web program
It uses a criterion called the conditional maximum likelihood to discriminate coding from non-coding features
HMM prediction is unbiased toward the locked region
If a sequence already has a sub-region identified as coding region, which may be based on similarity with cDNAs or proteins in a database, these regions are locked as coding regions

Discuss Question

Answer: Option C. -> HMM prediction is unbiased toward the locked region
Answer: (c).HMM prediction is unbiased toward the locked region