Questions and answers for exam Preparation

MCQs

Total Questions : 120 | Page 8 of 12 pages

Question 71. The genome annotation process involves two steps: gene prediction and functional assignment.

True
False
May be True or False
Can't say

Discuss Question

Answer: Option A. -> True
Answer: (a).True

Question 72. Which of the following is incorrect regarding gene ontology?

It exists because there is a need to standardize protein functional descriptions
It uses a limited vocabulary to describe molecular functions
Biological processes are not described though
The cellular components are described using limited vocabulary

Discuss Question

Answer: Option C. -> Biological processes are not described though
Answer: (c).Biological processes are not described though

Question 73. Which of the following is incorrect regarding gene annotation?

The gene annotation of the human genome employs a combination of theoretical prediction and experimental verification
Gene structures are first predicted by ab initio exon prediction programs
The predicted genes are compared with experimentally determined cDNA and EST sequences
The pairwise alignment programs are not involved

Discuss Question

Answer: Option D. -> The pairwise alignment programs are not involved
Answer: (d).The pairwise alignment programs are not involved

Question 74. Which of the following is incorrect regarding gene ontology?

There is standardization of the names and activities
There is no standardization of associated pathways
It provides consistency in describing overall protein functions
It facilitates grouping of proteins of related functions

Discuss Question

Answer: Option B. -> There is no standardization of associated pathways
Answer: (b).There is no standardization of associated pathways

Question 75. Which of the following is incorrect regarding Automated Genome Annotation?

It exists because of the need to develop fast and automated methods to annotate the genomic sequences
The automated approach relies on homology detection
The automated approach doesn’t rely on heuristic sequence similarity searching
Automation brings speed in gene annotation process

Discuss Question

Answer: Option C. -> The automated approach doesn’t rely on heuristic sequence similarity searching
Answer: (c).The automated approach doesn’t rely on heuristic sequence similarity searching

Question 76. It has been estimated that up to 11% of cDNA clones may be chimeric.

True
False
May be True or False
Can't say

Discuss Question

Answer: Option A. -> True
Answer: (a).True

Question 77. To generate EST data, clones in the cDNA library are randomly selected for sequencing from either end of the inserts.

True
False
May be True or False
Can't say

Discuss Question

Answer: Option A. -> True
Answer: (a).True

Question 78. Which of the following is untrue regarding the drawbacks of expressed sequence tags (ESTs)?

They are often of lowquality because they are automatically generated without verification
Many bases are ambiguously determined, represented by N’s
Frame shift errors and artifactual stop codons are some common errors
Despite of all the failures, the translation the sequences is smooth

Discuss Question

Answer: Option D. -> Despite of all the failures, the translation the sequences is smooth
Answer: (d).Despite of all the failures, the translation the sequences is smooth

Question 79. Which of the following is untrue regarding expressed sequence tags (ESTs)?

One of the high throughput approaches to genome-wide profiling of gene expression is sequencing ESTs
They are short sequences obtained from cDNA clones
They serve as short identifiers of full-length genes
They are typically in the range of 800 to 900 nucleotides in length

Discuss Question

Answer: Option D. -> They are typically in the range of 800 to 900 nucleotides in length
Answer: (d).They are typically in the range of 800 to 900 nucleotides in length

Question 80. Which of the following is untrue regarding expressed sequence tags (ESTs)?

EST libraries can be easily generated from various cell lines, tissues, organs, and at various developmental stages
Although individual ESTs are prone to error, an entire collection of ESTs contains valuable information
Identification of cDNA clone is difficult
ESTs can also facilitate the unique identification of a gene from a cDNA library

Discuss Question

Answer: Option C. -> Identification of cDNA clone is difficult
Answer: (c).Identification of cDNA clone is difficult