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MCQs

Total Questions : 120 | Page 7 of 12 pages
Question 61. The major challenges in genome assembly are sequence errors, contamination by bacterial vectors, and repetitive sequence regions.
  1.    True
  2.    False
  3.    May be True or False
  4.    Can't say
 Discuss Question
Answer: Option A. -> True
Answer: (a).True
Question 62. Which of the following is untrue about base calling and assembly programs?
  1.    The first step toward genome assembly includes derive base calls
  2.    The first step toward genome assembly includes assigning associated quality scores
  3.    One of the steps is to assemble the sequence reads into contiguous sequences
  4.    There is no identifying overlap between sequence fragments
 Discuss Question
Answer: Option D. -> There is no identifying overlap between sequence fragments
Answer: (d).There is no identifying overlap between sequence fragments
Question 63. When a sequence is generated from ____ ends of a single clone, the distance between the two opposing fragments of a clone is fixed to ________ meaning that they are always separated by a distance defined by a _____ length (normally 1,000 to 9,000 bases).
  1.    both, an uncertain range, clone
  2.    one, an uncertain range, clone
  3.    both, a certain range, clone
  4.    both, a certain range, gene
 Discuss Question
Answer: Option C. -> both, a certain range, clone
Answer: (c).both, a certain range, clone
Question 64. Which of the following is incorrect about Phred?
  1.    It is a UNIX program
  2.    It doesn’t give a probability score in output
  3.    It is used for base calling
  4.    It uses a Fourier analysis to resolve fluorescence traces and predict actual peak locations of bases
 Discuss Question
Answer: Option B. -> It doesn’t give a probability score in output
Answer: (b).It doesn’t give a probability score in output
Question 65. Which of the following is incorrect?
  1.    Initial DNA sequencing reactions generate short sequence reads from DNA clones
  2.    To assemble a whole genome sequence, these short fragments are joined to form larger fragments
  3.    The average length of the reads is about 50 bases
  4.    A number of overlapping contigs can be further merged to form scaffolds
 Discuss Question
Answer: Option C. -> The average length of the reads is about 50 bases
Answer: (c).The average length of the reads is about 50 bases
Question 66. Which of the following is incorrect about Phrap?
  1.    It aligns individual fragments in a pairwise fashion using the Smith–Waterman algorithm
  2.    It doesn’t take input from Phred
  3.    It is used for sequence assembly
  4.    It is a UNIX program
 Discuss Question
Answer: Option B. -> It doesn’t take input from Phred
Answer: (b).It doesn’t take input from Phred
Question 67. VecScreen is a primarily aimed for sequence assembly.
  1.    True
  2.    False
  3.    May be True or False
  4.    Can't say
 Discuss Question
Answer: Option B. -> False
Answer: (b).False
Question 68. TIGR Assembler is a UNIX program from TIGR for assembly of large shotgun sequence fragments.
  1.    True
  2.    False
  3.    May be True or False
  4.    Can't say
 Discuss Question
Answer: Option A. -> True
Answer: (a).True
Question 69. Which of the following is incorrect about ARACHNE?
  1.    It accepts base calls with associated quality scores assigned by Phred as input
  2.    It is a free UNIX program
  3.    It is for the assembly of whole-genome shotgun reads
  4.    It doesn’t involve heuristic approach
 Discuss Question
Answer: Option D. -> It doesn’t involve heuristic approach
Answer: (d).It doesn’t involve heuristic approach
Question 70. Which of the following is incorrect about EULER?
  1.    It is an assembly algorithm
  2.    It uses a Eulerian Superpath approach, which is a polynomial algorithm
  3.    In this approach, a sequence fragment is broken down to tuples of five nucleotides
  4.    The tuples are distributed in a diagram with numerous nodes that are all interconnected
 Discuss Question
Answer: Option C. -> In this approach, a sequence fragment is broken down to tuples of five nucleotides
Answer: (c).In this approach, a sequence fragment is broken down to tuples of five nucleotides

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