Questions and answers for exam Preparation

MCQs

Total Questions : 150 | Page 8 of 15 pages

Question 71. Which of the following is not a description of dynamic programming algorithm?

A method of sequence alignment
A method that can take gaps into account
A method that requires a manageable number of comparisons
This method doesn’t provide an optimal (highest scoring) alignment

Discuss Question

Answer: Option D. -> This method doesn’t provide an optimal (highest scoring) alignment
Answer: (d).This method doesn’t provide an optimal (highest scoring) alignment

Question 72. Dayhoff PAM matrices, are based on an evolutionary model of protein change, whereas, BLOSUM matrices, are designed to identify members of the same family.

True
False
May be True or False
Can't say

Discuss Question

Answer: Option A. -> True
Answer: (a).True

Question 73. Which of the following is not a site on internet for alignment of sequence pairs?

BLASTX
BLASTN
SIM
BCM Search Launcher

Discuss Question

Answer: Option A. -> BLASTX
Answer: (a).BLASTX

Question 74. A feature of the dynamic programming algorithm is that the alignments obtained depend on the choice of a scoring system for comparing character pairs and penalty scores for gaps.

True
False
May be True or False
Can't say

Discuss Question

Answer: Option A. -> True
Answer: (a).True

Question 75. Which of the following is untrue regarding dynamic programming algorithm?

The method compares every pair of characters in the two sequences and generates an alignment
The output alignment will include matched and mismatched characters and gaps in the two sequences that are positioned so that the number of matches between identical or related characters is the maximum possible
The dynamic programming algorithm provides a reliable computational method for aligning DNA and protein sequences
This doesn’t allow making evolutionary predictions on the basis of sequence alignments

Discuss Question

Answer: Option D. -> This doesn’t allow making evolutionary predictions on the basis of sequence alignments
Answer: (d).This doesn’t allow making evolutionary predictions on the basis of sequence alignments

Question 76. In scoring matrices, for convenience, odds scores are converted to log odds scores.

True
False
May be True or False
Can't say

Discuss Question

Answer: Option A. -> True
Answer: (a).True

Question 77. Which of the following doesn’t describe PAM matrices?

This family of matrices lists the likelihood of change from one amino acid to another in homologous protein sequences during evolution
There is presently no other type of scoring matrix that is based on such sound evolutionary principles as are these matrices
Even though they were originally based on a relatively small data set, the PAM matrices remain a useful tool for sequence alignment
It stands for Percent Altered Mutation

Discuss Question

Answer: Option D. -> It stands for Percent Altered Mutation
Answer: (d).It stands for Percent Altered Mutation

Question 78. The assumption in this evolutionary model is that the amino acid substitutions observed over short periods of evolutionary history can be extrapolated to longer distances.

True
False
May be True or False
Can't say

Discuss Question

Answer: Option A. -> True
Answer: (a).True

Question 79. The Dayhoff model of protein evolution is not a Markov process.

True
False
May be True or False
Can't say

Discuss Question

Answer: Option B. -> False
Answer: (b).False

Question 80. Which of the following is untrue about the modification of PAM matrices?

At one time, the PAM250 scoring matrix was modified in an attempt to improve the alignment obtained
All scores for matching a particular amino acid were normalized to the same mean and standard deviation, and all amino acid identities were given the same score to provide an equal contribution for each amino acid in a sequence alignment
This took place in 1976
These modifications were included as the default matrices for the GCG sequence alignment programs in versions 8 and earlier and are optional in later versions

Discuss Question

Answer: Option C. -> This took place in 1976
Answer: (c).This took place in 1976