Questions and answers for exam Preparation

MCQs

Total Questions : 150 | Page 15 of 15 pages

Question 141. Which of the following statements about COG is incorrect regarding its features?

Currently, there are 4,873 clusters in the COG databases derived from unicellular organisms
It is constructed by comparing protein sequences encoded in forty-three completely sequenced genomes, which are mainly from prokaryotes, representing thirty major phylogenetic lineages
The interface for sequence searching in the COG database is the COGnitor program, which is based on gapped BLAST
It is a protein family database based on structural classification

Discuss Question

Answer: Option D. -> It is a protein family database based on structural classification
Answer: (d).It is a protein family database based on structural classification

Question 142. Which of the following statements about SCOP is incorrect regarding its features?

Proteins with the same shapes but having little sequence or functional similarity are placed in different super families, and are assumed to have only a very distant common ancestor
Proteins having the same shape and some similarity of sequence and/or function are placed in ‘families’, and are assumed to have a closer common ancestor
SCOP was created in 1994 in the Centre of Protein Engineering and the University College London
It aims to determine the evolutionary relationship between proteins

Discuss Question

Answer: Option C. -> SCOP was created in 1994 in the Centre of Protein Engineering and the University College London
Answer: (c).SCOP was created in 1994 in the Centre of Protein Engineering and the University College London

Question 143. Which of the following statements about InterPro is incorrect regarding its features?

Protein relatedness is defined by the P-values from the BLAST alignments
The most closely related sequences are grouped into the lowest level clusters
More distant protein groups are merged into higher levels of clusters
The outcome of this cluster merging is a tree-like structure of functional categories

Discuss Question

Answer: Option A. -> Protein relatedness is defined by the P-values from the BLAST alignments
Answer: (a).Protein relatedness is defined by the P-values from the BLAST alignments

Question 144. Pfam is available at four locations around the world. Which of the following is not one of them?

UK
Sweden
US
Japan

Discuss Question

Answer: Option D. -> Japan
Answer: (d).Japan

Question 145. Which of the following is not a member database of InterPro?

SCOP
HAMAP
PANTHER
Pfam

Discuss Question

Answer: Option A. -> SCOP
Answer: (a).SCOP

Question 146. What is the source of protein structures in SCOP and CATH?

Uniprot
Protein Data Bank
Ensemble
InterPro

Discuss Question

Answer: Option B. -> Protein Data Bank
Answer: (b).Protein Data Bank

Question 147. Which of the following statements about PANTHER and TIGRFAMs databases is incorrect regarding its features?

TIGRFAMs provides a tool for identifying functionally related proteins based on sequence homology
TIGRFAMs is a collection of protein families, featuring curated multiple sequence alignments, hidden Markov models (HMMs) and annotation
Hidden Markov models (HMMs) are not used in PANTHER
PANTHER is a large collection of protein families that have been subdivided into functionally related subfamilies, using human expertise

Discuss Question

Answer: Option C. -> Hidden Markov models (HMMs) are not used in PANTHER
Answer: (c).Hidden Markov models (HMMs) are not used in PANTHER

Question 148. Which of the following statements about PRINTS and ProDom databases is incorrect regarding its features?

PRINTS is a compendium of protein fingerprints
Usually the motifs do not overlap, but are separated along a sequence, though they may be contiguous in 3D-space
Current versions of ProDom are built using a novel procedure based on recursive BLAST searches
ProDom domain database consists of an automatic compilation of homologous domains

Discuss Question

Answer: Option C. -> Current versions of ProDom are built using a novel procedure based on recursive BLAST searches
Answer: (c).Current versions of ProDom are built using a novel procedure based on recursive BLAST searches

Question 149. Which of the following statements about SUPERFAMILY database is incorrect regarding its features?

Sequences can be submitted raw or FASTA format
Sequences must be submitted in FASTA format only
It searches the database using a superfamily, family, or species name plus a sequence, SCOP, PDB or HMM ID’s
It has generated GO annotations for evolutionarily closed domains and distant domains

Discuss Question

Answer: Option B. -> Sequences must be submitted in FASTA format only
Answer: (b).Sequences must be submitted in FASTA format only

Question 150. Which of the following statements about CATH-Gene3D and HAMAP databases is incorrect regarding its features?

CATH-Gene3D describes protein families and domain architectures in complete genomes
In CATH-Gene3D the functional annotation is provided to proteins from single resource
HAMAP profiles are manually created by expert curators they identify proteins that are part of well-conserved bacterial, archaeal and plastid-encoded proteins families or subfamilies.
HAMAP stands for High-quality Automated and Manual Annotation of microbial Proteomes

Discuss Question

Answer: Option B. -> In CATH-Gene3D the functional annotation is provided to proteins from single resource
Answer: (b).In CATH-Gene3D the functional annotation is provided to proteins from single resource