Questions and answers for exam Preparation

MCQs

Total Questions : 150 | Page 6 of 15 pages

Question 51. What is used to generate parameters for the extreme distribution?

The pool of alignment scores from the shuffled sequences
A single score of a shuffled sequence
The pool of alignment scores from the unshuffled sequences
The basic optimal score computed at the beginning of the test

Discuss Question

Answer: Option A. -> The pool of alignment scores from the shuffled sequences
Answer: (a).The pool of alignment scores from the shuffled sequences

Question 52. Which of the following is untrue about the PRSS program?

It stands for Probability of Random Shuffles
It is a web-based program that can be used to evaluate the statistical significance of DNA or protein sequence alignment
It first aligns two sequences using the Needleman-Wunsch algorithm and calculates the score
It holds one sequence in its original form and randomizes the order of residues in the other sequence.

Discuss Question

Answer: Option C. -> It first aligns two sequences using the Needleman-Wunsch algorithm and calculates the score
Answer: (c).It first aligns two sequences using the Needleman-Wunsch algorithm and calculates the score

Question 53. If the score is located in the extreme margin of the distribution, that means that the alignment between the two sequences is ______ due to random chance and is thus considered ______

unlikely, significant
unlikely, insignificant
unlikely, insignificant
very likely, significant

Discuss Question

Answer: Option A. -> unlikely, significant
Answer: (a).unlikely, significant

Question 54. It is not known whether the Gumble distribution applies equally well to gapped alignments.

True
False
May be True or False
Can't say

Discuss Question

Answer: Option A. -> True
Answer: (a).True

Question 55. The major disadvantage of the PRSS program is that it doesn’t allow partial shuffling.

True
False
May be True or False
Can't say

Discuss Question

Answer: Option B. -> False
Answer: (b).False

Question 56. Which of the following is not an advantage of Statistical models’ methods in analyzing protein motifs?

Sequence information is preserved from a multiple sequence alignment and expresses it with probabilistic models
Statistical models allow partial matches and compensate for unobserved sequence patterns using pseudo-counts
Statistical models have stronger predictive power than the regular expression based approach, even when they are derived from a limited set of sequences
The comparative flexibility is less in case of these methods when compared to regular expressions methods

Discuss Question

Answer: Option D. -> The comparative flexibility is less in case of these methods when compared to regular expressions methods
Answer: (d).The comparative flexibility is less in case of these methods when compared to regular expressions methods

Question 57. Which of the following is not an advantageous feature or algorithm of the database PRINTS?

This program breaks down a motif into even smaller non-overlapping units called ‘fingerprints’, which are represented by unweighted PSSMs
To define a motif, at least a majority of fingerprints are required to match with a query sequence
A query that has simultaneous high-scoring matches to a majority of fingerprints belonging to a motif is a good indication of containing the functional motif
The difficulty to recognize short motifs when they reach the size of single fingerprints

Discuss Question

Answer: Option D. -> The difficulty to recognize short motifs when they reach the size of single fingerprints
Answer: (d).The difficulty to recognize short motifs when they reach the size of single fingerprints

Question 58. For motif scanning which of the following programs or databases is for regulated sites curated from scientific literature?

ENSEMBL
ORegAnno
MAST
Clover

Discuss Question

Answer: Option B. -> ORegAnno
Answer: (b).ORegAnno

Question 59. In which of the following multipurpose packages Gibbs sampling algorithm is used?

Consensus
BEST
AlignACE
PhyloCon

Discuss Question

Answer: Option C. -> AlignACE
Answer: (c).AlignACE

Question 60. Which of the following is untrue in case of the database BLOCKS?

The alignments are automatically generated using the same data sets used for deriving the BLOSUM matrices
The derived ungapped alignments are called ‘blocks’, which are usually longer than motifs, are subsequently converted to PSSMs
A weighting scheme and pseudo counts are subsequently applied to the PSSMs to account for underrepresented and unobserved residues in alignments
The functional annotation of blocks is not consistent with that for the motifs

Discuss Question

Answer: Option D. -> The functional annotation of blocks is not consistent with that for the motifs
Answer: (d).The functional annotation of blocks is not consistent with that for the motifs