Questions and answers for exam Preparation

MCQs

Total Questions : 100 | Page 7 of 10 pages

Question 61. Which of the following is untrue about profile method?

A profile is constructed for a group of related protein structures
The propensity of amino acids in not in picture of this method
Statistical information from these aligned residues is then used to construct a profile
The structural profile is generated by the superimposition of the structures to expose corresponding residues

Discuss Question

Answer: Option B. -> The propensity of amino acids in not in picture of this method
Answer: (b).The propensity of amino acids in not in picture of this method

Question 62. Which of the following is untrue about threading and fold recognition?

It assess the compatibility of an amino acid sequence with a known structure in a fold library
If the protein fold to be predicted does not exist in the fold library, the method won’t necessarily fail
If the protein fold to be predicted does not exist in the fold library, the method will fail
Threading and fold recognition do not generate fully refined atomic models for the query sequences

Discuss Question

Answer: Option B. -> If the protein fold to be predicted does not exist in the fold library, the method won’t necessarily fail
Answer: (b).If the protein fold to be predicted does not exist in the fold library, the method won’t necessarily fail

Question 63. Because threading and fold recognition detect structural homologs ________ relying on sequence similarities, they have been shown to be _______ than PSI-BLAST in finding distant evolutionary relationships

without completely, far more sensitive
completely, far more sensitive
completely, less sensitive
without completely, less sensitive

Discuss Question

Answer: Option A. -> without completely, far more sensitive
Answer: (a).without completely, far more sensitive

Question 64. Which of the following is untrue about 3D-PSSM?

It is a web-based program that employs the structural profile method to identify protein folds
The profiles for each protein superfamily are constructed by combining multiple smaller profiles
A protein structural superfamily doesn’t have sequence-based PSI-BLAST profile
In initial steps, protein structures in a superfamily based on the SCOP classification are superimposed

Discuss Question

Answer: Option C. -> A protein structural superfamily doesn’t have sequence-based PSI-BLAST profile
Answer: (c).A protein structural superfamily doesn’t have sequence-based PSI-BLAST profile

Question 65. Which of the following is true about Gen Threader?

It is a web-based program that uses a hybrid of the profile and pairwise energy methods
It is a web-based program that uses profile methods only
It is a web-based program that uses pairwise energy methods only
The initial step is quite dissimilar to 3D-PSSM

Discuss Question

Answer: Option A. -> It is a web-based program that uses a hybrid of the profile and pairwise energy methods
Answer: (a).It is a web-based program that uses a hybrid of the profile and pairwise energy methods

Question 66. The classification results from both systems, SCOP and CATH are quite dissimilar.

True
False
May be True or False
Can't say

Discuss Question

Answer: Option B. -> False
Answer: (b).False

Question 67. The second step in structure classification is to separate structurally distinct domains within a structure.

True
False
May be True or False
Can't say

Discuss Question

Answer: Option A. -> True
Answer: (a).True

Question 68. Which of the following is untrue about SCOP?

It is a database for comparing and classifying protein structures
It is constructed almost entirely based on manual examination of protein structures
The proteins are grouped into hierarchies of classes, folds, superfamilies, and families
The SCOP families consist of proteins having low sequence identity (>30%)

Discuss Question

Answer: Option D. -> The SCOP families consist of proteins having low sequence identity (>30%)
Answer: (d).The SCOP families consist of proteins having low sequence identity (>30%)

Question 69. The last step in structure classification involves grouping proteins/domains of similar structures.