Questions and answers for exam Preparation

MCQs

Total Questions : 100 | Page 4 of 10 pages

Question 31. The formation of _____ is determined by ______ interactions, whereas the formation of ____ is strongly influenced by ______ interactions.

α-helices, long-range, α-helices, short-range
α-helices, long-range, β-strands, short-range
α-helices, short-range, β-strands, long-range
β-strands, short-range, β-strands, long-range

Discuss Question

Answer: Option C. -> α-helices, short-range, β-strands, long-range
Answer: (c).α-helices, short-range, β-strands, long-range

Question 32. Which of the following is untrue regarding Ab Initio–Based Methods?

This type of method predicts the secondary structure based on a single query sequence
This type of method predicts the secondary structure based on a multiple query sequence
It measures the relative propensity of each amino acid belonging to a certain secondary structure element
The propensity scores are derived from known crystal structures

Discuss Question

Answer: Option B. -> This type of method predicts the secondary structure based on a multiple query sequence
Answer: (b).This type of method predicts the secondary structure based on a multiple query sequence

Question 33. The Chou–Fasman algorithm determines the propensity or intrinsic tendency of each residue to be in the helix, strand, and β-turn conformation using observed frequencies found in protein crystal structures.

True
False
May be True or False
Can't say

Discuss Question

Answer: Option A. -> True
Answer: (a).True

Question 34. The secondary structure prediction methods can be either ab initio based, which make use of single sequence information only, or homology based, which makes use of multiple sequence alignment information.

True
False
May be True or False
Can't say

Discuss Question

Answer: Option A. -> True
Answer: (a).True

Question 35. The GOR method is based on the “propensity” of each residue to be in one of the two conformational states, helix (H), strand(E).

True
False
May be True or False
Can't say

Discuss Question

Answer: Option B. -> False
Answer: (b).False

Question 36. Which of the following is untrue regarding Chou–Fasman and GOR methods?

Both are the first-generation methods
They are developed in the 1970s
They suffer from the fact that the prediction rules are somewhat arbitrary
They are based on single sequence statistics with clear relation to known protein-folding theories

Discuss Question

Answer: Option D. -> They are based on single sequence statistics with clear relation to known protein-folding theories
Answer: (d).They are based on single sequence statistics with clear relation to known protein-folding theories

Question 37. Which of the following is untrue regarding Prediction with Neural Networks?

The third-generation prediction algorithms extensively apply sophisticated neural networks
It is used to analyze substitution patterns in multiple sequence alignments
It is not a machine learning process
It requires a structure of multiple layers of interconnected variables or nodes

Discuss Question

Answer: Option C. -> It is not a machine learning process
Answer: (c).It is not a machine learning process

Question 38. Which of the following is untrue regarding Prediction with Neural Networks?

It has to be first trained by sequences with known structures
Between input and output are many connected hidden layers
Between the connected hidden layers the machine learning takes place to adjust the mathematical weights of internal connections
It doesn’t have to be first trained by sequences with known structures

Discuss Question

Answer: Option D. -> It doesn’t have to be first trained by sequences with known structures
Answer: (d).It doesn’t have to be first trained by sequences with known structures

Question 39. Which of the following is untrue regarding Homology-Based Methods?

The third generation of algorithms was developed in the late 1990s
They were developed by making use of evolutionary information
This type of method uses the ab initio secondary structure prediction of individual sequences only
This type of method combines the ab initio secondary structure prediction of individual sequences and alignment information from multiple homologous sequences (>35% identity)

Discuss Question

Answer: Option C. -> This type of method uses the ab initio secondary structure prediction of individual sequences only
Answer: (c).This type of method uses the ab initio secondary structure prediction of individual sequences only

Question 40. Because residues in the same aligned position are assumed to have the same secondary structure, any inconsistencies or errors in prediction of individual sequences can be corrected using a majority rule.