Questions and answers for exam Preparation

MCQs

Total Questions : 165 | Page 8 of 17 pages

Question 71. Sequencing of genomes depends on the assembly of a large number of DNA reads into a linear, contiguous DNA sequence.

True
False
May be True or False
Can't say

Discuss Question

Answer: Option A. -> True
Answer: (a).True

Question 72. In case of genome sequence assembly which of the given statement is incorrect?

Full chromosomal sequences are assembled from the overlaps in a highly redundant set of fragments by an automatic computational method or from the fragment order on a physical map
Chromosome cloning is carried out in bacterial artifical chromosomes (BACs)
Chromosomes of a target organism are purified, fragmented, and subcloned in fragments of size hundreds of bp
Genome sequences are assembled from DNA sequence fragments of approximate length 500 bp obtained using DNA sequencing machines

Discuss Question

Answer: Option C. -> Chromosomes of a target organism are purified, fragmented, and subcloned in fragments of size hundreds of bp
Answer: (c).Chromosomes of a target organism are purified, fragmented, and subcloned in fragments of size hundreds of bp

Question 73. TEs (Transposable Elements) can at most comprise one-fourth of the genome sequence.

True
False
May be True or False
Can't say

Discuss Question

Answer: Option B. -> False
Answer: (b).False

Question 74. Screening the predicted protein sequences against ______ library confirms the prediction and expression of the gene.

expressed sequence tag (EST)
tags
palindromes
proteomes

Discuss Question

Answer: Option A. -> expressed sequence tag (EST)
Answer: (a).expressed sequence tag (EST)

Question 75. Each genome sequence is scanned for protein-encoding genes using gene models trained on known gene sequences from the same organism.

True
False
May be True or False
Can't say

Discuss Question

Answer: Option A. -> True
Answer: (a).True

Question 76. Gene identification in prokaryotic organisms is simplified by their lacking _________

exons
introns
coding segments
useful nucleotide sequences

Discuss Question

Answer: Option B. -> introns
Answer: (b).introns

Question 77. Which of the given statement is incorrect?

The predicted set of proteins for the genome is referred to as the proteome
The amino acid sequence of proteins encoded by the predicted genes is used as a query of the protein sequence databases in a database similarity search
A match of a predicted protein sequence to one or more database sequences serves only to identify the gene function but it doesn’t validate the gene prediction
The genome sequence is annotated with the information on gene content and predicted structure, gene location, and functional predictions

Discuss Question

Answer: Option C. -> A match of a predicted protein sequence to one or more database sequences serves only to identify the gene function but it doesn’t validate the gene prediction
Answer: (c).A match of a predicted protein sequence to one or more database sequences serves only to identify the gene function but it doesn’t validate the gene prediction

Question 78. Which of the given statement is incorrect about the gene map?

Gene order in two related organisms reflects the order that was present in a common ancestor genome. Chromosomal breaks followed by reassembly of fragments in a different order can produce new gene maps
Gene order is only revealed by the physical order of genes on the chromosome
Sequence variations (polymorphisms) that are close to (tightly linked) a trait may be used to trace the trait by virtue of the fact that the polymorphism and the trait are seldom separated from one generation to the next
These types of evolutionary changes in genomes have been modeled by computational methods

Discuss Question

Answer: Option B. -> Gene order is only revealed by the physical order of genes on the chromosome
Answer: (b).Gene order is only revealed by the physical order of genes on the chromosome

Question 79. Which of the given statement is incorrect about Functional Genomics?

Functional genomics involves the preparation of mutant or transgenic organisms with a mutant form of a particular gene usually designed to prevent expression of the gene
An abnormal properties of the mutant organism does not reveal the gene function
When two or more members of a gene family are found, rather than a single match to a known gene, the biological activity of these members may be analyzed by functional genomics to look for diversification of function in the family
A more detailed analysis of the relative amount of sequence variability in a chromosomal region within populations of closely related species can reveal the presence of genes that are under selection

Discuss Question

Answer: Option B. -> An abnormal properties of the mutant organism does not reveal the gene function
Answer: (b).An abnormal properties of the mutant organism does not reveal the gene function

Question 80. Which of the following information is not directly obtained by microarray analysis?

Which genes are expressed at a particular stage of the cell cycle
Which genes are expressed at a particular stage of developmental cycle of an organism
Which genes are depleted at what time
Genes that respond to a given environmental signal to the same extent

Discuss Question

Answer: Option C. -> Which genes are depleted at what time
Answer: (c).Which genes are depleted at what time