Questions and answers for exam Preparation

MCQs

Total Questions : 165 | Page 16 of 17 pages

Question 151. In SVMs (Support vector machines) Data points are log-transformed and normalized as in method A, where for N observations of a gene i, the log transform Xi of the expression level Ei and reference level Ri is?

Xi = \(\frac{Log (E_i/R_i)}{\sqrt{\sum_{j=1,N} Log_{z-2} (E_j/R_j)}}\)
Xj = \(\frac{Log (E_j/R_i)}{\sqrt{\sum_{j=1,N} Log_z (E_j/R_j)}}\)
Xi = \(\frac{Log (E_i/R_i)}{\sqrt{\sum_{j=1,(N-1)} Log_z (E_j/R_j)}}\)
Xi = \(\frac{Log (E_i/R_i)}{\sqrt{\sum_{j=1,N} Log_z (E_j/R_j)}}\)

Discuss Question

Answer: Option A. -> Xi = \(\frac{Log (E_i/R_i)}{\sqrt{\sum_{j=1,N} Log_{z-2} (E_j/R_j)}}\)
Answer: (a).Xi = \(\frac{Log (E_i/R_i)}{\sqrt{\sum_{j=1,N} Log_{z-2} (E_j/R_j)}}\)

Question 152. In Genome-wide prediction of protein functions by a combinatorial method– Each point represents a protein, and branches between proteins indicate a relationship by one of several criteria indicated in the legend.

True
False
May be True or False
Can't say

Discuss Question

Answer: Option A. -> True
Answer: (a).True

Question 153. When two proteins share a considerable degree of sequence identity throughout the sequence alignment, they are least likely to share the same function.

True
False
May be True or False
Can't say

Discuss Question

Answer: Option B. -> False
Answer: (b).False

Question 154. Which of the given statement is untrue about functional genomics?

Known functions are derived from experimental evidence in molecular biology and genetic studies with model organisms
Non-Orthologous genes between biologically distinct species can be identified, and it is strong evidence for a related function
Sequence-based methods of gene prediction can be augmented by the types of genome comparisons that are designed to identify related genes based on common patterns of expression, evolutionary profiles, chromosomal locations, and other features
Genome analysis depends to a large extent on sequence analysis methods that identify gene function based on similarity between proteins of unknown function and proteins of known function

Discuss Question

Answer: Option B. -> Non-Orthologous genes between biologically distinct species can be identified, and it is strong evidence for a related function
Answer: (b).Non-Orthologous genes between biologically distinct species can be identified, and it is strong evidence for a related function

Question 155. Other types of evidence for a relationship between two genes are also given that are not dependent in sequence similarity. Which of the following is a wrong statement?

genes are closely linked on the same chromosomes
genes are transcribed from the same DNA strand
gene fusions are observed between otherwise separate genes
phylogenetic profiles show the genes are not that commonly present in organisms

Discuss Question

Answer: Option D. -> phylogenetic profiles show the genes are not that commonly present in organisms
Answer: (d).phylogenetic profiles show the genes are not that commonly present in organisms

Question 156. Investigators are encouraged to submit their newly obtained sequences directly to a member of the International Nucleotide Sequence Database Collaboration, such as the NCBI, DDBJ, and EMBL.

True
False
May be True or False
Can't say

Discuss Question

Answer: Option A. -> True
Answer: (a).True

Question 157. Which of the given statements is incorrect?

The simplest and newest way of submitting sequences is through the Web site on a Web form page called BankIt
The sequence can also be annotated with information about the sequence, such as mRNA start and coding regions
The submitted form is transformed into GenBank format and returned to the submitter for review before being added to GenBank
Sequin does not run on UNIX

Discuss Question

Answer: Option D. -> Sequin does not run on UNIX
Answer: (d).Sequin does not run on UNIX

Question 158. Granting agency requires a certain level of accuracy in case of errors. Which of the given statements is untrue regarding it?

In other laboratories, such as those performing a single-attempt sequencing of ESTs, the error rate may be much higher, approximately 1 in 100, including incorrectly identified bases and inserted or deleted bases
Incorrect bases always translate to the right amino acid
Base insertions/deletions will cause frame-shifts in the sequence
Making alignment with a protein sequence becomes difficult because of frameshifts

Discuss Question

Answer: Option B. -> Incorrect bases always translate to the right amino acid
Answer: (b).Incorrect bases always translate to the right amino acid

Question 159. NCBI reviews new entries and updates existing ones, as requested.

True
False
May be True or False
Can't say

Discuss Question

Answer: Option A. -> True
Answer: (a).True

Question 160. Which of the given statements is untrue?

There is no detailed check of sequence accuracy prior to submission to GenBank and other databases
Often, a sequence is submitted at the time of publication of the sequence in a journal article, providing a certain level of checking by the editorial peer review process
No sequence is submitted without being published or prior to publication
In laboratories performing large sequencing projects, such as those engaged in the Human Genome Project or the genome projects of model organisms, the granting agency requires a certain level of accuracy of the order of 1 possible error per 10 kb

Discuss Question

Answer: Option C. -> No sequence is submitted without being published or prior to publication
Answer: (c).No sequence is submitted without being published or prior to publication