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MCQs

Total Questions : 43 | Page 4 of 5 pages
Question 31. . Combined cellular and humoral immune deficiencies result from lack of all of the following except
  1.    a thymus
  2.    class II MHC
  3.    HIV infection of CD4+ T cells
  4.    transporter of antigen peptides (TAP)
 Discuss Question
Answer: Option D. -> transporter of antigen peptides (TAP)
Question 32. . An example of an immunodeficiency disorder is
  1.    thyroiditis
  2.    rheumatic fever
  3.    systemic lupus erythematosus
  4.    AIDS
 Discuss Question
Answer: Option D. -> AIDS
Question 33. . Bone marrow given to an infant with SCID must
  1.    be irradiated to eliminate GVHD
  2.    contain mature T cells that can begin making immune responses immediately
  3.    come from a donor that shares some MHC alleles with the recipient
  4.    come from one of the child's parents
 Discuss Question
Answer: Option C. -> come from a donor that shares some MHC alleles with the recipient
Question 34. .  X-linked hyper IgM syndrome, resulting in high levels of serum IgM and low levels of serum IgG, is caused by a defect in CD40L expression. The specific immune event that would be prevented by a defective CD40L would be
  1.    activation of B cells by T-independent antigens
  2.    failure of B cells to provide co-stimulation for Th2 activation
  3.    failure of Th2 cells to provide co-stimulation for B cell isotype switching
  4.    ailure of Th2 cells to provide co-stimulation for B cell proliferation
 Discuss Question
Answer: Option C. -> failure of Th2 cells to provide co-stimulation for B cell isotype switching
Question 35. . Which of the Rous sarcoma virus has a homologous cellular protein?
  1.    c-src
  2.    v-src
  3.    v-ha-src
  4.    v-ha-ras
 Discuss Question
Answer: Option A. -> c-src
Question 36. . DiGeorge's syndrome is characterized by the lack of a thymus The mouse model closest to this human disease would be a
  1.    knock-out mouse for RAG-1 and RAG-2
  2.    knock-out mouse for a thymus
  3.    nude mouse
  4.    recombinant mouse for CD3
 Discuss Question
Answer: Option C. -> nude mouse
Question 37. . The chemical, typically released by the body in an allergic response is
  1.    histamine
  2.    allergens
  3.    antihistamines
  4.    perforins
 Discuss Question
Answer: Option A. -> histamine
Question 38. . Infants are most susceptible to bacterial infection due to low circulating levels of IgG
  1.    in utero (before birth)
  2.    at 0-3 months of age
  3.    at 3-12 months of age
  4.    at 12-24 months of age
 Discuss Question
Answer: Option C. -> at 3-12 months of age
Question 39. .  X-linked hyper IgM syndrome, resulting in high levels of serum IgM and low levels of serum IgG, is caused by a defect in CD40L expression. The specific immune event that would be prevented by a defective CD40L would be
  1.    activation of B cells by T-independent antigens
  2.    failure of B cells to provide co-stimulation for Th2 activation
  3.    failure of Th2 cells to provide co-stimulation for B cell isotype switching
  4.    ailure of Th2 cells to provide co-stimulation for B cell proliferation
 Discuss Question
Answer: Option C. -> failure of Th2 cells to provide co-stimulation for B cell isotype switching
Question 40. . Which of the Rous sarcoma virus has a homologous cellular protein?
  1.    c-src
  2.    v-src
  3.    v-ha-src
  4.    v-ha-ras
 Discuss Question
Answer: Option A. -> c-src

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