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MCQs

Total Questions : 43 | Page 2 of 5 pages
Question 11. Combined cellular and humoral immune deficiencies result from lack of all of the following except
  1.    transporter of antigen peptides (TAP)
  2.    HIV infection of CD4+ T cells
  3.    a thymus
  4.    class II MHC
 Discuss Question
Answer: Option A. -> transporter of antigen peptides (TAP)
Question 12. Bone marrow given to an infant with SCID must
  1.    come from a donor that shares some MHC alleles with the recipient
  2.    contain mature T cells that can begin making immune responses immediately
  3.    be irradiated to eliminate GVHD
  4.    come from one of the child's parents
 Discuss Question
Answer: Option A. -> come from a donor that shares some MHC alleles with the recipient
Question 13. A selective IgA deficiency would be expected to result in problems with
  1.    pathogens which can survive inside macrophages
  2.    bacterial infections
  3.    mucosal pathogens
  4.    infections following dental work due to bacteria entering the bloodstream
 Discuss Question
Answer: Option C. -> mucosal pathogens
Question 14. An example of an immunodeficiency disorder is
  1.    systemic lupus erythematosus
  2.    AIDS
  3.    thyroiditis
  4.    rheumatic fever
 Discuss Question
Answer: Option B. -> AIDS
Question 15. X-linked hyper IgM syndrome, resulting in high levels of serum IgM and low levels of serum IgG, is caused by a defect in CD40L expression. The specific immune event that would be prevented by a defective CD40L would be
  1.    activation of B cells by T-independent antigens
  2.    failure of Th2 cells to provide co-stimulation for B cell proliferation
  3.    failure of Th2 cells to provide co-stimulation for B cell isotype switching
  4.    failure of B cells to provide co-stimulation for Th2 activation
 Discuss Question
Answer: Option C. -> failure of Th2 cells to provide co-stimulation for B cell isotype switching
Question 16. DiGeorge's syndrome is characterized by the lack of a thymus The mouse model closest to this human disease would be a
  1.    knock-out mouse for a thymus
  2.    knock-out mouse for RAG-1 and RAG-2
  3.    nude mouse
  4.    recombinant mouse for CD3
 Discuss Question
Answer: Option C. -> nude mouse
Question 17. Which of the Rous sarcoma virus has a homologous cellular protein?
  1.    c-src
  2.    v-src
  3.    v-ha-ras
  4.    v-ha-src
 Discuss Question
Answer: Option A. -> c-src
Question 18. Infants are most susceptible to bacterial infection due to low circulating levels of IgG
  1.    at 3-12 months of age
  2.    in utero (before birth)
  3.    at 0-3 months of age
  4.    at 12-24 months of age
 Discuss Question
Answer: Option A. -> at 3-12 months of age
Question 19. The chemical, typically released by the body in an allergic response is
  1.    antihistamines
  2.    allergens
  3.    perforins
  4.    histamine
 Discuss Question
Answer: Option D. -> histamine
Question 20.  The HIV virus infects primarily
  1.    brain cells
  2.    cells in the immune system
  3.    red blood cells
  4.    liver cells
 Discuss Question
Answer: Option B. -> cells in the immune system

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