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MCQs

Total Questions : 43 | Page 3 of 5 pages
Question 21.  Difficulties with somatic gene therapy arise from all of the following except
  1.    GVHD caused by mature T cells in the transplanted cells
  2.    inserting a gene so that it will function properly
  3.    limited life span of more mature hematopoietic cells
  4.    transducing genetic material into stem cells
 Discuss Question
Answer: Option A. -> GVHD caused by mature T cells in the transplanted cells
Question 22.  
Chronic granulomatous disease results from a failure to perform oxidative burst. This deficiency would be most likely to interfere with
  1.    CTL killing of viruses
  2.    dendritic cell activation to become a mature APC
  3.    infected cell processing of virus peptides
  4.    macrophage intracellular killing of bacteria
 Discuss Question
Answer: Option D. -> macrophage intracellular killing of bacteria
Question 23.  
If Class IIMHC is not expressed in the thymus, the resulting immune deficiencies would include all of the following except reduced
  1.    alternative complement activation.
  2.    CD8 T cell-mediated cytotoxicity
  3.    macrophage activation to vesicular pathogens
  4.    IgG synthesis
 Discuss Question
Answer: Option A. -> alternative complement activation.
Question 24.  An autoimmune disease is
  1.    AIDS
  2.    Measles
  3.    Lupus
  4.    Mumps
 Discuss Question
Answer: Option C. -> Lupus
Question 25.  
A monoclonal antibody (mAb) specific for the 2,4-dinitrophenyl (DNP) hapten might also bind
  1.    Leu or Ileu
  2.    His or Pro
  3.    Tyr or Phe
  4.    Ser or Thr
 Discuss Question
Answer: Option C. -> Tyr or Phe
Question 26.  Retinoblastoma is due to a mutation in a
  1.    kinase
  2.    tumor supressor
  3.    cyclin
  4.    viral gene
 Discuss Question
Answer: Option B. -> tumor supressor
Question 27.  Specific translocations are associated with
  1.    colon cancer
  2.    breast cancer
  3.    pancreatic cancer
  4.    some leukemias
 Discuss Question
Answer: Option D. -> some leukemias
Question 28.  To treat HIV infections using drugs, the major problem is that
  1.    the drugs that are good inhibitors cannot by synthesized
  2.    the drugs interfere with normal digestion
  3.    the virus particles with altered (mutant) proteases arise
  4.    the drugs are rapidly degraded
 Discuss Question
Answer: Option B. -> the drugs interfere with normal digestion
Question 29. . The primary reason for AIDS, a deadly disease is that it
  1.    is caused by a virus
  2.    is caused by a bacterium
  3.    destroys key components of the body's internal defense system
  4.    causes a breakdown of the body's inflammatory response
 Discuss Question
Answer: Option C. -> destroys key components of the body's internal defense system
Question 30. . A selective IgA deficiency would be expected to result in problems with
  1.    bacterial infections
  2.    infections following dental work due to bacteria entering the bloodstream
  3.    mucosal pathogens
  4.    pathogens which can survive inside macrophages
 Discuss Question
Answer: Option C. -> mucosal pathogens

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