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MCQs

Total Questions : 61 | Page 3 of 7 pages
Question 21. How much time does an intravenously administered drug take to complete a complete circulation?
  1.    5-8 min
  2.    7-10 min
  3.    1-3 min
  4.    1 min
 Discuss Question
Answer: Option C. -> 1-3 min
Answer: (c).1-3 min
Question 22. The i.v. bolus dosage is 500mg and the plasma drug concentration is 0.8 mg/ml. What should be the volume of distribution?
  1.    625 mg/ml
  2.    625 l
  3.    625 ml
  4.    0.0016 mg/ml
 Discuss Question
Answer: Option C. -> 625 ml
Answer: (c).625 ml
Question 23. To have a plasma distribution value of 900 ml and plasma drug concentration to be 1.2 mg/ml what should be the amount of drug that should be given to the patient?
  1.    1080 ml
  2.    1080 g
  3.    1080 mg
  4.    1g/ml
 Discuss Question
Answer: Option C. -> 1080 mg
Answer: (c).1080 mg
Question 24. What is the equation to find out hepatic clearance?
  1.    Plasma drug concentration/rate of elimination by the kidney
  2.    Rate of elimination by kidney/plasma drug concentration
  3.    1 / rate of elimination by the kidney
  4.    1 / plasma drug concentration
 Discuss Question
Answer: Option B. -> Rate of elimination by kidney/plasma drug concentration
Answer: (b).Rate of elimination by kidney/plasma drug concentration
Question 25. Which organs comprise the central compartment in a two compartment model?
  1.    Muscles
  2.    Skin
  3.    Adipose
  4.    Liver
 Discuss Question
Answer: Option D. -> Liver
Answer: (d).Liver
Question 26. Which organ comprises the peripheral compartment in a two compartment model?
  1.    Liver
  2.    Lungs
  3.    Kidneys
  4.    Muscles
 Discuss Question
Answer: Option D. -> Muscles
Answer: (d).Muscles
Question 27. Which of the following is not a category of 2 compartment model?
  1.    Two compartment model with elimination from the central compartment
  2.    Two compartment model with elimination from the peripheral compartment
  3.    Two compartment model with elimination from only plasma and blood
  4.    Two compartment model with elimination from both the compartments
 Discuss Question
Answer: Option D. -> Two compartment model with elimination from both the compartments
Answer: (d).Two compartment model with elimination from both the compartments
Question 28. Which one of these are correct Michaelis-Menten equation?
  1.    –dC/dt = Vmax C/Km+C
  2.    dC/dt = Vmax C/Km+C
  3.    –dC/dt = Vmax C/Km
  4.    –dC/dt = Km+C/Vmax C
 Discuss Question
Answer: Option A. -> –dC/dt = Vmax C/Km+C
Answer: (a).–dC/dt = Vmax C/Km+C
Question 29. Any changes in fraction bioavailable, elimination half-life indicates nonlinearity of that particular drug.
  1.    True
  2.    False
  3.    May be True or False
  4.    Can't say
 Discuss Question
Answer: Option A. -> True
Answer: (a).True
Question 30. Which of the following creates nonlinearity in drug distribution and not in drug absorption?
  1.    When absorption is solubility or dissolution rate-limited
  2.    When absorption involves carrier-mediated transport systems
  3.    When a presystemic gut wall or hepatic metabolism attains saturation
  4.    Saturation of binding sites on plasma proteins
 Discuss Question
Answer: Option D. -> Saturation of binding sites on plasma proteins
Answer: (d).Saturation of binding sites on plasma proteins

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