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Question
Which of the following creates nonlinearity in drug distribution and not in drug absorption?
Options:
A .  When absorption is solubility or dissolution rate-limited
B .  When absorption involves carrier-mediated transport systems
C .  When a presystemic gut wall or hepatic metabolism attains saturation
D .  Saturation of binding sites on plasma proteins
Answer: Option D
Answer: (d).Saturation of binding sites on plasma proteins
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