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MCQs

Total Questions : 179 | Page 7 of 18 pages
Question 61. Heroin with pKa 7.8 will be in which form in intestinal pH?
  1.    Ionized form mostly
  2.    Unionized form mostly
  3.    Half ionized and half no ionized
  4.    Will form aggregate
 Discuss Question
Answer: Option B. -> Unionized form mostly
Answer: (b).Unionized form mostly
Question 62. All drugs which are weak acids or acidic in nature will be in a unionized form in the plasma.
  1.    True
  2.    False
  3.    May be True or False
  4.    Can't say
 Discuss Question
Answer: Option B. -> False
Answer: (b).False
Question 63. Nitrazepam a weak base, will be in which form in the stomach?
  1.    Ionized form mostly
  2.    Non-ionized form mostly
  3.    Half ionized and half no ionized
  4.    Will form aggregate
 Discuss Question
Answer: Option A. -> Ionized form mostly
Answer: (a).Ionized form mostly
Question 64. Which one of these options is not one of the limitations of pH-partition theory?
  1.    Presence if virtual membrane pH
  2.    Absorption of ionized drugs
  3.    Influence of GI surface area
  4.    Dissolution rate
 Discuss Question
Answer: Option D. -> Dissolution rate
Answer: (d).Dissolution rate
Question 65. A microclimate pH, different from the luminal pH exists at the membrane surface.
  1.    True
  2.    False
  3.    May be True or False
  4.    Can't say
 Discuss Question
Answer: Option A. -> True
Answer: (a).True
Question 66. According to the pH-partition theory which form of the drug gets absorbed mostly?
  1.    Hydrated form
  2.    Aggregated form
  3.    Ionised
  4.    Unionised
 Discuss Question
Answer: Option D. -> Unionised
Answer: (d).Unionised
Question 67. What helps the ionized drug molecules to pass through the cell membrane passively?
  1.    Different pH
  2.    Polar group
  3.    Large lipophilic group
  4.    Hydration
 Discuss Question
Answer: Option C. -> Large lipophilic group
Answer: (c).Large lipophilic group
Question 68. What could be the reason that irrespective of pH any drug gets absorbed mostly from the intestine?
  1.    More surface area
  2.    Long residence time
  3.    Large surface area and long residence time
  4.    Large surface area, long residence time, basic pH
 Discuss Question
Answer: Option C. -> Large surface area and long residence time
Answer: (c).Large surface area and long residence time
Question 69. Acidic drugs are best absorbed through the stomach and basic drugs are best absorbed through the intestine.
  1.    True
  2.    False
  3.    May be True or False
  4.    Can't say
 Discuss Question
Answer: Option A. -> True
Answer: (a).True
Question 70. Drug having a small partition coefficient can rapidly penetrate the lipid membrane but diffusion through the unstirred water layer is a rate-limiting step.
  1.    True
  2.    False
  3.    May be True or False
  4.    Can't say
 Discuss Question
Answer: Option B. -> False
Answer: (b).False

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