Question
What is the correct order in which the factors of clotting are affected in order for blood to clot?
Answer: Option D
:
D
When the blood vessels are damaged they attract platelets. The damaged endothelial cells express tissue factor. The tissue factor initiates a coagulation cascade.The end result of the cascade is the formation of an enzyme called prothrombinase.This prothrombinase cleaves prothrombin giving rise to thrombin.The platelets have specific thrombin receptors; the thrombin attaches to the platelets and forms a weak plate plug. Thrombin acts on fibrinogen in the plasma and cleaves it to form insoluble fibrin strands.The insoluble fibrin strands are then stabilized to form a clot by fibrin stabilizing factor which is also activated by thrombin.
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:
D
When the blood vessels are damaged they attract platelets. The damaged endothelial cells express tissue factor. The tissue factor initiates a coagulation cascade.The end result of the cascade is the formation of an enzyme called prothrombinase.This prothrombinase cleaves prothrombin giving rise to thrombin.The platelets have specific thrombin receptors; the thrombin attaches to the platelets and forms a weak plate plug. Thrombin acts on fibrinogen in the plasma and cleaves it to form insoluble fibrin strands.The insoluble fibrin strands are then stabilized to form a clot by fibrin stabilizing factor which is also activated by thrombin.
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