Which of the given statements is incorrect about Clusters of orthologous groups?

Question

Options:

A . Paralogs may include a best hit or a high-scoring match of one of the sequences by another, but the reciprocal match can have low similarity that does not have to be significant

B . Paralogs defined by sets of three matching sequences in the selected organisms were kept separated from the clusters

C . Orthologous pairs were first defined by the best hits in reciprocal searches

D . To produce COGs, similarity searches were performed among the proteomes of phylogenetically distinct clades of prokaryotes

Answer: Option B
Answer: (b).Paralogs defined by sets of three matching sequences in the selected organisms were kept separated from the clusters

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