These limitations of the Zuker method and other methods have been largely overco

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These limitations of the Zuker method and other methods have been largely overcome by using an algorithm originally described by Waterman and Byers (1985) for finding sequence alignments within a certain range of the optimal one by modifications of the trace-back procedure used in dynamic programming.

Options:

A . True

B . False

C . May be True or False

D . Can't say

Answer: Option A
Answer: (a).True

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Question 1. Three scores, Pnum (i), Hnum (i,j), and Ssum, have been derived to assist with a determination of the reliability of a s....Which of the following is not a correct regarding Ssum?

Question 2. A limitation of the Zuker method and other methods (Nakaya et al. 1995) for computing suboptimal RNA structures is that ....within a given energy range of the minimum free-energy structure.

Question 3. Three scores, Pnum (i), Hnum (i,j), and Ssum, have been derived to assist with a determination of the reliability of a s....of the following is not a correct regarding Hnum?

Question 4. At present, there are essentially two types of method of RNA structure prediction. One is the minimum free energy approa....energy approach and the Second one is a comparative approach.

Question 5. Ab initio approach makes structural predictions based on ______....

Question 6. In ab initio approach, generally, when a base pairing is formed, the energy of the molecule is _________ because of attr....is _________ because of attractive interactions between the two strands.

Question 7. In ab initio methods, free energy can be calculated based on parameters empirically derived for small molecules.....

Question 8. The energy necessary to form individual base pairs is not quite affected by adjacent base pairs.....

Question 9. In dot matrix in ab initio methods, the diagonals _____________ to the main diagonal represent regions that can self hyb....to the main diagonal represent regions that can self hybridize.

Question 10. In dot matrix in ab initio methods, one way to reduce the noise in the matrix is to select an appropriate window size of....window size of a maximum number of contiguous base matches.

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