To solve this question, we'll first rearrange the letters in each word in alphabetical order:

(A) Code: cdeo
(B) Lack: ackl
(C) Meet: eemt
(D) Deaf: adef
(E) Road: ador

Now, let's rearrange the groups of letters formed alphabetically:

1. adef (from "Deaf")
2. ackl (from "Lack")
3. ador (from "Road")
4. cdeo (from "Code")
5. eemt (from "Meet")

Now, we see that there are five groups of letters. Since there is an odd number of groups, the middle group will be the third one when arranged alphabetically.

So, the word with its group of letters in the middle is "Road" (Option E).