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MCQs

Total Questions : 18 | Page 2 of 2 pages
Question 11. . The cleavage specificity of trypsin and chymotrypsin depend in part on the
  1.    proximity of Ser 195 to the active site or specificity pocket
  2.    size, shape, and charge of the active site or specificity pocket
  3.    presence of a low-barrier hydrogen bond in the active site or specificity pocket
  4.    absence of water in the active site
 Discuss Question
Answer: Option B. -> size, shape, and charge of the active site or specificity pocket
Question 12.  The nucleophile in serine proteases is
  1.    Serine
  2.    water
  3.    both (a) and (b)
  4.    Asparagine
 Discuss Question
Answer: Option C. -> both (a) and (b)
Question 13. . Which of the common features are shared between serine and aspartate proteases?
  1.    Both require water to complete the catalytic cycle
  2.    Both use a base to activate the nucleophile
  3.    Both show specificity for certain amino acid sequences
  4.    All of the above
 Discuss Question
Answer: Option D. -> All of the above
Question 14. . Before they can react, many molecules need to be destabilized. This state is typically achieved through
  1.    changing the three-dimensional shape of the molecule
  2.    oxidizing the molecules by removing electrons
  3.    changing the reaction from a biosynthetic to a catabolic pathway
  4.    the input of a small amount of activation energy
 Discuss Question
Answer: Option D. -> the input of a small amount of activation energy
Question 15. . 
Common feature in all serine proteases is a
  1.    hydrophobic specificity pocket
  2.    hydrophilic specificity pocket
  3.    cluster of reactive serine residues
  4.    single reactive serine residue
 Discuss Question
Answer: Option D. -> single reactive serine residue
Question 16. . How is the enzyme COX-1 important in human health?
  1.    It helps to transport carbon dioxide in the blood
  2.    It is critical for the biosynthesis of DNA
  3.    It is a chemical derivative of aspirin
  4.    It catalyzes the production of hormones that maintain the stomach lining
 Discuss Question
Answer: Option D. -> It catalyzes the production of hormones that maintain the stomach lining
Question 17. . 
Common feature in all serine proteases is a
  1.    hydrophobic specificity pocket
  2.    hydrophilic specificity pocket
  3.    cluster of reactive serine residues
  4.    single reactive serine residue
 Discuss Question
Answer: Option D. -> single reactive serine residue
Question 18. . How is the enzyme COX-1 important in human health?
  1.    It helps to transport carbon dioxide in the blood
  2.    It is critical for the biosynthesis of DNA
  3.    It is a chemical derivative of aspirin
  4.    It catalyzes the production of hormones that maintain the stomach lining
 Discuss Question
Answer: Option D. -> It catalyzes the production of hormones that maintain the stomach lining

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