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MCQs

Total Questions : 26 | Page 2 of 3 pages
Question 11. The specificity of a ligand binding site on a protein is based on
  1.    the amino acid residues lining the binding site
  2.    the presence of hydrating water molecules
  3.    the absence of competing ligands
  4.    the opposite chirality of the binding ligand
 Discuss Question
Answer: Option A. -> the amino acid residues lining the binding site
Question 12.  The conformational changes from the T to the R state is initiated by
  1.    binding of oxygen to the heme
  2.    movement of the proximal histidine towards the heme
  3.    movement of the F-helix, which contains the proximal His
  4.    reorganization of protein-protein contacts between the individual subunits
 Discuss Question
Answer: Option A. -> binding of oxygen to the heme
Question 13.  An allosteric activator
  1.    increases the binding affinity
  2.    decreases the binding affinity
  3.    stabilizes the R state of the protein
  4.    both (a) and (c)
 Discuss Question
Answer: Option D. -> both (a) and (c)
Question 14.  Bisphosphoglycerate (BPG) cannot bind to the oxygenated R state of hemoglobin because
  1.    it is displaced from the heme by oxygen
  2.    it is displaced from the heme by movement of the proximal histidine
  3.    its binding pocket becomes too small to accommodate BPG
  4.    BPG binds to the R state with the same affinity as the T state
 Discuss Question
Answer: Option C. -> its binding pocket becomes too small to accommodate BPG
Question 15.  The Hill coefficient (nH) for myoglobin and hemoglobin are respectively
  1.    2.8 and 1.0
  2.    1.0 and 2.8
  3.    1.2 and 4.5
  4.    4.5 and 1.2
 Discuss Question
Answer: Option B. -> 1.0 and 2.8
Question 16.  
When protein binds two ligands in a non-cooperative manner, then the x-intercept of the Scatchard Plot is
  1.    1
  2.    2
  3.    not defined
  4.    none of the above
 Discuss Question
Answer: Option B. -> 2
Question 17.  O2 binding to hemoglobin results in
  1.    100-fold higher affinity for the last O2 bound than for the first
  2.    extensive protein conformational change
  3.    both (a) and (b)
  4.    100-fold lower affinity for the last O2 bound than for the first
 Discuss Question
Answer: Option C. -> both (a) and (b)
Question 18.  In hemoglobin, allosteric effects occur
  1.    only in humans
  2.    for maintaining Fe in the Fe2+ state
  3.    to minimize oxygen delivery to the tissues
  4.    to maximize oxygen delivery to the tissues
 Discuss Question
Answer: Option D. -> to maximize oxygen delivery to the tissues
Question 19.  
A protein that binds two ligands in a non-cooperative manner will show
  1.    a sigmodial binding curve
  2.    a hyperbolic binding curve
  3.    a linear Scatchard Plot
  4.    both (b) and (c)
 Discuss Question
Answer: Option D. -> both (b) and (c)
Question 20.  Small molecules affect hemoglobin (Hb) by
  1.    decreasing Hb affinity for O2
  2.    increasing [H+]
  3.    increasing Hb affinity for O2
  4.    increasing [H+] and decreasing Hb affinity for O2
 Discuss Question
Answer: Option D. -> increasing [H+] and decreasing Hb affinity for O2

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