X-linked hyper IgM syndrome, resulting in high levels of serum IgM and low level

Question

X-linked hyper IgM syndrome, resulting in high levels of serum IgM and low levels of serum IgG, is caused by a defect in CD40L expression. The specific immune event that would be prevented by a defective CD40L would be

Options:

A . activation of B cells by T-independent antigens

B . failure of Th2 cells to provide co-stimulation for B cell proliferation

C . failure of Th2 cells to provide co-stimulation for B cell isotype switching

D . failure of B cells to provide co-stimulation for Th2 activation

Answer: Option C

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