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1.  Clinical trials have limitations beyond their exorbitant costs and the years or decades it takes them to provide meaningful results.
A.  Randomly subjecting thousands of individuals to second-hand tobacco smoke, pollutants or potentially noxious trans fats presents obvious ethical dilemmas.
B.  Clinical trials invariably enroll subjects who are relatively healthy, who are motivated to volunteer and will show up regularly for treatments and checkups.
C.  They can rarely be used, for instance, to study suspected harmful effects.
D.  And even when these trials are done to study the benefits of a particular intervention, it's rarely clear how the results apply to the public at large or to any specific patient.
6.  Randomized trials are very good for showing that a drug does what the pharmaceutical company says it does but not very good for telling you how big the benefit really is and whatare the harms in typical people.
 
Options:
A .  ABCD
B .  BADC
C .  CADB
D .  DCBA
Answer: Option C
:
C
Sentence B cannot follow A because both of them start with the phrase 'clinical trials', which isredundant.A pronoun should have replaced the subject 'clinical trials' in order to make the flowcoherent.So [b] and [e] can be negated.CD is not a valid link - C precisely states the drawbackof using clinical trials' whereas D goes off on a tangent.Hence, [a] is also negated.Sentence Aends on a negative note regarding the clinical trials whereas sentence 6 begins on a positive note about the trials and again goes on to discuss the negative aspects.Moreover, aBA link also cannot be established - B mentions the health of the subjects whereasAmentions a different issue regarding the subjects (ethical dilemmas associated with trials conducted on them).Therefore, [d] can be negated.Ccan follow A because it states what other problem is associated with clinical trials and it should be followed by A which gives some examples. D should follow A because of the connecting phrase 'and even when'.So the proper sequenceis CADB.
SHORTCUT
Look at sentence 1
"Clinical trials have limitations beyond their exorbitant costs and the years or decades it takes them to provide meaningful results.”
We need to look for a sentence which lets us look at some more limitations. Only sentence C fits the bill. Only one option starts C. Hence, answer is option (c)

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