Questions and answers for exam Preparation

MCQs

Total Questions : 90 | Page 2 of 9 pages

Question 11. Originally, the FOLD program of _____ predicted _____ having the minimum free energy.

M. Zuker, two structures
M. Wunsch, two structures
M. Zuker, only one
M. Wunsch, only one

Discuss Question

Answer: Option C. -> M. Zuker, only one
Answer: (c).M. Zuker, only one

Question 12. In the programs related to FOLD, All complementary base pairs can be sampled in a fashion to determine which are present in a suboptimal structure.

True
False
May be True or False
Can't say

Discuss Question

Answer: Option A. -> True
Answer: (a).True

Question 13. The program may be instructed to find structures within a certain percentage of the minimum free energy.

True
False
May be True or False
Can't say

Discuss Question

Answer: Option A. -> True
Answer: (a).True

Question 14. To find suboptimal structures, the dynamic programming method was modified.

True
False
May be True or False
Can't say

Discuss Question

Answer: Option A. -> True
Answer: (a).True

Question 15. In the programs related to FOLD, the second region, the ________ region, is used to calculate the energy of the ________ structure.

included, most likely
included, best
excluded, least likely
excluded, best

Discuss Question

Answer: Option D. -> excluded, best
Answer: (d).excluded, best

Question 16. Three scores, Pnum (i), Hnum (i,j), and Ssum, have been derived to assist with a determination of the reliability of a secondary structure prediction for a particular base i or a base pair i,j. Which of the following is not a correct regarding Pnum?

is the total number of energy dots regardless of color in the i th row and i th column of the energy dot plot
is the total number of energy dots considering the color in the ith row and ith column of the energy dot plot
represents in an unfiltered dot plot
represents the number of base pairs

Discuss Question

Answer: Option B. -> is the total number of energy dots considering the color in the ith row and ith column of the energy dot plot
Answer: (b).is the total number of energy dots considering the color in the ith row and ith column of the energy dot plot

Question 17. These limitations of the Zuker method and other methods have been largely overcome by using an algorithm originally described by Waterman and Byers (1985) for finding sequence alignments within a certain range of the optimal one by modifications of the trace-back procedure used in dynamic programming.

True
False
May be True or False
Can't say

Discuss Question

Answer: Option A. -> True
Answer: (a).True

Question 18. Three scores, Pnum (i), Hnum (i,j), and Ssum, have been derived to assist with a determination of the reliability of a secondary structure prediction for a particular base i or a base pair i,j. Which of the following is not a correct regarding Ssum?

is also called as ss-count
is the number of foldings in which base i is single-stranded divided by m, the number of folding
is the number of foldings in which base i is single-stranded multiplied by m, the number of folding
gives the probability that base i is single-stranded

Discuss Question

Answer: Option C. -> is the number of foldings in which base i is single-stranded multiplied by m, the number of folding
Answer: (c).is the number of foldings in which base i is single-stranded multiplied by m, the number of folding

Question 19. A limitation of the Zuker method and other methods (Nakaya et al. 1995) for computing suboptimal RNA structures is that they do not compute all the structures within a given energy range of the minimum free-energy structure.

True
False
May be True or False
Can't say

Discuss Question

Answer: Option A. -> True
Answer: (a).True

Question 20. Three scores, Pnum (i), Hnum (i,j), and Ssum, have been derived to assist with a determination of the reliability of a secondary structure prediction for a particular base i or a base pair i,j. Which of the following is not a correct regarding Hnum?

is the sum of Pnum(i) and Pnum(j) -1
is the sum of Pnum(i) and Pnum(j) + 1
is the total number of dots in the ith row and jth column
represents the total number of base pairs with the ith or jth base in the predicted structures

Discuss Question

Answer: Option B. -> is the sum of Pnum(i) and Pnum(j) + 1
Answer: (b).is the sum of Pnum(i) and Pnum(j) + 1