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MCQs

Total Questions : 63 | Page 6 of 7 pages
Question 51. The phylogenetic profile method relies on detection of orthologs (or homologs, in a variation of the method) in a set of genomes.
  1.    True
  2.    False
  3.    May be True or False
  4.    Can't say
 Discuss Question
Answer: Option A. -> True
Answer: (a).True
Question 52. Due to the requirement for co-regulation as well as colocalization, the method is mostly limited to certain classes of protein-protein interactions.
  1.    True
  2.    False
  3.    May be True or False
  4.    Can't say
 Discuss Question
Answer: Option A. -> True
Answer: (a).True
Question 53. In the assessment of methods to predict protein-protein interactions, one third of such pairs were found to physically interact, and an additional third to belong to the same metabolic pathway or functional process.
  1.    True
  2.    False
  3.    May be True or False
  4.    Can't say
 Discuss Question
Answer: Option A. -> True
Answer: (a).True
Question 54. Proteins are dynamic entities that undergo _______
  1.    only fluctuation of flexible loop regions about equilibrium positions when in solution
  2.    only limited conformational change of amino acid side-chains when in solution
  3.    both limited conformational change of amino acid side-chains and fluctuation of flexible loop regions about equilibrium positions when in solution
  4.    illimitable or total conformational change of amino acid side-chains when in solution
 Discuss Question
Answer: Option C. -> both limited conformational change of amino acid side-chains and fluctuation of flexible loop regions about equilibrium positions when in solution
Answer: (c).both limited conformational change of amino acid side-chains and fluctuation of flexible loop regions about equilibrium positions when in solution
Question 55. In Multiple conformation rigid-body method, a ligand is assumed to be able to adopt a number (N) of different _______ that are computed _____ the ligand being docked into the receptor.
  1.    low-energy conformations, after
  2.    low-energy conformations, prior to
  3.    high-energy conformations, prior to
  4.    high-energy conformations, after
 Discuss Question
Answer: Option B. -> low-energy conformations, prior to
Answer: (b).low-energy conformations, prior to
Question 56. Typical motions of proteins will be primarily treated by a rigid body model for docking.
  1.    True
  2.    False
  3.    May be True or False
  4.    Can't say
 Discuss Question
Answer: Option B. -> False
Answer: (b).False
Question 57. In case of Protein-ligand docking, ______ ligands are often _____ in adapting their shape to fit the receptor binding pocket.
  1.    small molecule, highly flexible
  2.    large molecule, highly flexible
  3.    large molecule, more flexible
  4.    small molecule, less flexible
 Discuss Question
Answer: Option A. -> small molecule, highly flexible
Answer: (a).small molecule, highly flexible
Question 58. The disadvantage of Multiple conformation rigid-body method is that the active conformation may be missed as the result of a minor structural difference not considered in the ______ ligand conformations. Where, the N is the number of low-energy conformations.
  1.    N +1
  2.    N
  3.    N²
  4.    N/2
 Discuss Question
Answer: Option B. -> N
Answer: (b).N
Question 59. In protein domain family interaction map, the physical contacts of the domains in different families are represented by the lines between the nodes.
  1.    True
  2.    False
  3.    May be True or False
  4.    Can't say
 Discuss Question
Answer: Option A. -> True
Answer: (a).True
Question 60. In the Interaction map of domain families, the interactions of one family represent the sum of all the interactions of domains in that family.
  1.    True
  2.    False
  3.    May be True or False
  4.    Can't say
 Discuss Question
Answer: Option A. -> True
Answer: (a).True

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