Bioinformatics

GENOMICS AND PROTEOMICS MCQs

Total Questions : 120

Page 1 of 12 pages
Question 1. Which of the following is untrue about Lateral gene transfer?
  1.    It is also known as vertical gene transfer
  2.    There is exchange of genetic materials between species
  3.    It mainly occurs among prokaryotic organisms when foreign genes are acquired through mechanisms
  4.    It is one of the examples is transformation
 Discuss Question
Answer is Option A. -> It is also known as vertical gene transfer
Answer: (a).It is also known as vertical gene transfer
Question 2. A way to discern lateral gene transfer is through phylogenetic analysis, referred to as an ‘among-genome’ approach, which can be used to discover __________
  1.    recent lateral gene transfer events but almost negligible ancient events
  2.    recent lateral gene transfer events
  3.    ancient lateral gene transfer events
  4.    both recent and ancient lateral gene transfer events
 Discuss Question
Answer is Option D. -> both recent and ancient lateral gene transfer events
Answer: (d).both recent and ancient lateral gene transfer events
Question 3. Which of the following is untrue about Gene Order Comparison?
  1.    When the order of a number of linked genes is conserved between genomes, it is called synteny
  2.    Generally, gene order is much more conserved compared with gene sequences
  3.    Generally, gene order is much less conserved compared with gene sequences
  4.    It is in fact rarely observed among divergent species
 Discuss Question
Answer is Option B. -> Generally, gene order is much more conserved compared with gene sequences
Answer: (b).Generally, gene order is much more conserved compared with gene sequences
Question 4. Genes involved in the same metabolic pathway tend to be clustered among phylogenetically diverse organisms.
  1.    True
  2.    False
  3.    May be True or False
  4.    Can't say
 Discuss Question
Answer is Option A. -> True
Answer: (a).True
Question 5. Within-Genome Approach is to identify regions within a genome with unusual compositions.
  1.    True
  2.    False
  3.    May be True or False
  4.    Can't say
 Discuss Question
Answer is Option A. -> True
Answer: (a).True
Question 6. Which of the following is incorrect about a microarray?
  1.    It is a slide attached with a high-density array of immobilized DNA oligomers representing the entire genome of the species under study
  2.    Array of immobilized DNA oligomers cannot be cDNAs
  3.    Each oligomer is spotted on the slide and serves as a probe for binding to a unique complementary cDNA
  4.    It is the most commonly used global gene expression profiling method
 Discuss Question
Answer is Option B. -> Array of immobilized DNA oligomers cannot be cDNAs
Answer: (b).Array of immobilized DNA oligomers cannot be cDNAs
Question 7. In the analysis of microarray data–If replicated datasets are available, rigorous statistical tests such as t-test and analysis of variance (ANOVA) can be performed to test the null hypothesis that a given data point is not significantly different from the mean of the data distribution.
  1.    True
  2.    False
  3.    May be True or False
  4.    Can't say
 Discuss Question
Answer is Option A. -> True
Answer: (a).True
Question 8. Which of the following is incorrect about Oligonucleotide Design in A microarray?
  1.    DNA microarrays are generated by fixing oligonucleotides onto a solid support
  2.    The oligonucleotide array slide represents thousands of preselected genes from an organism
  3.    The length of oligonucleotides is typically in the range of twenty-five to seventy bases long
  4.    The oligonucleotides don’t react with cDNA samples
 Discuss Question
Answer is Option D. -> The oligonucleotides don’t react with cDNA samples
Answer: (d).The oligonucleotides don’t react with cDNA samples
Question 9. Which of the following is incorrect about Classification of microarray data?
  1.    For microarray data, clustering analysis identifies coexpressed and coregulated genes
  2.    For microarray data, clustering analysis identifies coexpressed but not coregulated genes
  3.    For microarray data, clustering analysis identifies and coregulated but not coexpressed genes
  4.    Genes within a category have more similarity in expression than genes from different categories.
 Discuss Question
Answer is Option A. -> For microarray data, clustering analysis identifies coexpressed and coregulated genes
Answer: (a).For microarray data, clustering analysis identifies coexpressed and coregulated genes
Question 10. Which of the following is incorrect about Data Collection?
  1.    The two-color microarray uses multiple dyes at times
  2.    The most common type of microarray protocol is the two-color microarray
  3.    The cDNAs are obtained by extracting total RNA or mRNA from tissues or cells and incorporating fluorescent dyes in the DNA strands during the cDNA biosynthesis
  4.    The expression of genes is measured via the signals from cDNAs hybridizing with the specific oligonucleotide probes on the microarray
 Discuss Question
Answer is Option A. -> The two-color microarray uses multiple dyes at times
Answer: (a).The two-color microarray uses multiple dyes at times