Bioinformatics

DATABASE SIMILARITY SEARCHING MCQs

Total Questions : 50

Page 1 of 5 pages
Question 1. Local sequence alignments are necessary for many cases out of which one is repeated.
  1.    True
  2.    False
  3.    May be True or False
  4.    Can't say
 Discuss Question
Answer is Option A. -> True
Answer: (a).True
Question 2. One of the challenges in SWA is obtaining correct alignments in regions of low similarity between distantly related biological sequences.
  1.    True
  2.    False
  3.    May be True or False
  4.    Can't say
 Discuss Question
Answer is Option A. -> True
Answer: (a).True
Question 3. In SW algorithm, to align two sequences of lengths of m and n _________ time is required.
  1.    O(mn)
  2.    O(m²n)
  3.    O(m²n³)
  4.    O(mn²)
 Discuss Question
Answer is Option B. -> O(m²n)
Answer: (b).O(m²n)
Question 4. The function of the scoring matrix is to conduct one-to-one comparisons between all components in two sequences and record the optimal alignment results.
  1.    True
  2.    False
  3.    May be True or False
  4.    Can't say
 Discuss Question
Answer is Option A. -> True
Answer: (a).True
Question 5. Score can be negative in Smith–Waterman algorithm.
  1.    True
  2.    False
  3.    May be True or False
  4.    Can't say
 Discuss Question
Answer is Option B. -> False
Answer: (b).False
Question 6. The BLAST program was developed in _______
  1.    1992
  2.    1995
  3.    1990
  4.    1991
 Discuss Question
Answer is Option C. -> 1990
Answer: (c).1990
Question 7. In sequence alignment by BLAST, each word from query sequence is typically _______ residues for protein sequences and _______ residues for DNA sequences.
  1.    ten, eleven
  2.    three, three
  3.    three, eleven
  4.    three, ten
 Discuss Question
Answer is Option C. -> three, eleven
Answer: (c).three, eleven
Question 8. In sequence alignment by BLAST, the second step is to search a sequence database for the occurrence of these words.
  1.    True
  2.    False
  3.    May be True or False
  4.    Can't say
 Discuss Question
Answer is Option A. -> True
Answer: (a).True
Question 9. A recent improvement in the implementation of BLAST is the ability to provide gapped alignment.
  1.    True
  2.    False
  3.    May be True or False
  4.    Can't say
 Discuss Question
Answer is Option A. -> True
Answer: (a).True
Question 10. The final step involves pairwise alignment by extending from the words in both directions while counting the alignment score using the same substitution matrix.
  1.    True
  2.    False
  3.    May be True or False
  4.    Can't say
 Discuss Question
Answer is Option A. -> True
Answer: (a).True