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MCQs

Total Questions : 26 | Page 1 of 3 pages
Question 1. The conformational changes from the T to the R state is initiated by
  1.    reorganization of protein-protein contacts between the individual subunits
  2.    movement of the F-helix, which contains the proximal His
  3.    binding of oxygen to the heme
  4.    movement of the proximal histidine towards the heme
 Discuss Question
Answer: Option C. -> binding of oxygen to the heme
Question 2. Bisphosphoglycerate (BPG) cannot bind to the oxygenated R state of hemoglobin because
  1.    it is displaced from the heme by oxygen
  2.    its binding pocket becomes too small to accommodate BPG
  3.    it is displaced from the heme by movement of the proximal histidine
  4.    BPG binds to the R state with the same affinity as the T state
 Discuss Question
Answer: Option B. -> its binding pocket becomes too small to accommodate BPG
Question 3. An allosteric activator
  1.    both (a) and (c)
  2.    decreases the binding affinity
  3.    stabilizes the R state of the protein
  4.    increases the binding affinity
 Discuss Question
Answer: Option A. -> both (a) and (c)
Question 4. When protein binds two ligands in a non-cooperative manner, then the x-intercept of the Scatchard Plot is
  1.    2
  2.    1
  3.    not defined
  4.    None of these
 Discuss Question
Answer: Option A. -> 2
Question 5. The Hill coefficient (nH) for myoglobin and hemoglobin are respectively
  1.    1.2 and 4.5
  2.    1.0 and 2.8
  3.    2.8 and 1.0
  4.    4.5 and 1.2
 Discuss Question
Answer: Option B. -> 1.0 and 2.8
Question 6. Small molecules affect hemoglobin (Hb) by
  1.    decreasing Hb affinity for O2
  2.    increasing [H+]
  3.    increasing Hb affinity for O2
  4.    increasing [H+] and decreasing Hb affinity for O2
 Discuss Question
Answer: Option D. -> increasing [H+] and decreasing Hb affinity for O2
Question 7. In hemoglobin, allosteric effects occur
  1.    for maintaining Fe in the Fe2+ state
  2.    to minimize oxygen delivery to the tissues
  3.    only in humans
  4.    to maximize oxygen delivery to the tissues
 Discuss Question
Answer: Option D. -> to maximize oxygen delivery to the tissues
Question 8. A protein that shows infinite cooperative for binding of n ligands will
  1.    only be found in either the unliganded form or the fully liganded form
  2.    show a Hill coefficient (nH) of 0.0
  3.    both (b) and (c)
  4.    show a Hill coefficient (nH) of n
 Discuss Question
Answer: Option C. -> both (b) and (c)
Question 9. A protein that binds two ligands in a non-cooperative manner will show
  1.    a hyperbolic binding curve
  2.    a sigmodial binding curve
  3.    both (b) and (c)
  4.    a linear Scatchard Plot
 Discuss Question
Answer: Option C. -> both (b) and (c)
Question 10. O2 binding to hemoglobin results in
  1.    100-fold lower affinity for the last O2 bound than for the first
  2.    both (a) and (b)
  3.    extensive protein conformational change
  4.    100-fold higher affinity for the last O2 bound than for the first
 Discuss Question
Answer: Option B. -> both (a) and (b)

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