Question
Glutamic acid H2N−CH(CH2CH2COOH)−COOHN has pKa1(α−COOH)=2.2,pKa2(R group COOH)=4.3. The isoelectric point of glutamic acid is
Answer: Option D
:
D
H3+N−CH|CH2CH2COOHCationicform−COOHOnneutralisation⟶1stionizationH3+N−CH|CH2CH2COOH−COO−⟶2ndionizationH3+N−CH|CH2CH2COO−−COO−
Isoelectricpoin(pI)=pKa1+pKa32
2.2+4.32=3.25
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:
D
H3+N−CH|CH2CH2COOHCationicform−COOHOnneutralisation⟶1stionizationH3+N−CH|CH2CH2COOH−COO−⟶2ndionizationH3+N−CH|CH2CH2COO−−COO−
Isoelectricpoin(pI)=pKa1+pKa32
2.2+4.32=3.25
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